Cortical Astrocytes-Inhibitory Neurons Communication Define Opposite Social Profiles in 22q11.2 and 7q11.23 Deletion Syndromes

We developed innovative techniques to explore evolutionary conserved brain functions in social situations. Here, to understand the brain mechanisms causing distinct social behavioral alterations, we will focus on two specific genetic conditions: the 22q11.2 and the 7q11.23 deletion syndromes, also known as DiGeorge and Williams-Beuren syndromes, respectively. Notably, these two genetic conditions lead to opposite social phenotypes, respectively hypo- and hyper-social functioning.

Using cutting-edge tools like genetic analysis, single-cell live imaging, and optogenetics, we will investigate within a specific area of the brain, the prefrontal cortex (PFC), the communication between different types of brain cells — inhibitory interneurons and astrocytes. By unraveling the roles of these cells in distinct social behaviors, we aim to gain insights into the mechanisms that drive social alterations in these genetic syndromes.

Comparing these two genetic conditions with opposite social phenotypes provides a unique opportunity to delve deep into the complexities of social dysfunctions. The goal is to uncover cell-specific and circuit-specific mechanisms underlying socio-cognitive dysfunctions. This knowledge could serve as the foundation for understanding psychiatric-relevant behaviors and developing more effective treatments for social disorders.