ANALYSIS OF APOPTOSIS IN NEURODEGENERATIVE DISEASES BY APAF1 CONDITIONAL MUTAGENESIS

Scientific Publications

• 2008 MOLECULAR BIOLOGY OF THE CELL

  Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis

• 2007 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

  Autophagic and apoptotic response to stress signals in mammalian cells

• 2009 JOURNAL OF ALZHEIMERS DISEASE

  Early Biochemical and Morphological Modifications in the Brain of a Transgenic Mouse Model of Alzheimer's Disease: A Role for Peroxisomes

• 2010 CELL DEATH AND DIFFERENTIATION

  Neuronal caspase-3 signaling: not only cell death

• 2008 CELL DEATH AND DIFFERENTIATION

  The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy?

• 2008 MICROBES AND INFECTION

  Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells

• 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME

  Apoptosis is not required for mammalian neural tube closure

• 2008 AUTOPHAGY

  Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

• 2007 CANCER BIOLOGY & THERAPY

  Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance

• 2011 NATURE NEUROSCIENCE

  Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

• 2008 METHODS IN ENZYMOLOGY

  Analysis of neuronal cell death in mammals

• 2008 PHARMACEUTICAL RESEARCH

  The apoptosome: Emerging insights and new potential targets for drug design

• 2008 CELLULAR AND MOLECULAR LIFE SCIENCES

  Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells

• 2011 JOURNAL OF CELL SCIENCE

  Apaf1 plays a pro-survival role by regulating centrosome morphology and function

• 2007 MOLECULAR CELL

  Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

• 2006 APOPTOSIS

  Apoptosome impairment during development results in activation of an autophagy program in cerebral cortex

• 2011 EMBO JOURNAL

  Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

• 2007 AUTOPHAGY

  A novel role for autophagy in neurodevelopment

• 2010 CELL DEATH AND DIFFERENTIATION

  A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

• 2010 DEVELOPMENTAL BIOLOGY

  Foregut separation and tracheo-oesophageal malformations: The role of tracheal outgrowth, dorso-ventral patterning and programmed cell death

• 2014 PLOS ONE

  Altered Mitochondria Morphology and Cell Metabolism in Apaf1-Deficient Cells

• 2007 NATURE

  Ambra1 regulates autophagy and development of the nervous system

• 2008 DEVELOPMENTAL CELL

  The role of autophagy in mammalian development: Cell makeover rather than cell death

• 2009 CELL CYCLE

  A novel player in the p53-mediated autophagy Sestrin2

• 2007 DEVELOPMENT

  Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis

• 2008 AUTOPHAGY

  A dual role of p53 in the control of autophagy